Scientists Discover Restless Legs Syndrome Gene
July 19, 2007
An international team of researchers has identified the first gene associated with Restless Legs Syndrome (RLS), a common sleep disorder affecting tens of millions of people worldwide. The findings will be published July 18 in the online edition of the New England Journal of Medicine and will appear in an upcoming printed edition of the journal. The work was led by scientists at Emory University and deCODE Genetics, Inc., in Reykjavik, Iceland.
Restless legs syndrome is a condition that produces an intense, often irresistible urge to move the legs and is a major cause of insomnia and sleep disruption. RLS affects approximately 10 percent of the U.S. population and about one percent of school-aged children. The discovery provides strong new evidence that RLS is a genuine syndrome, a fact which has recently been the subject of some debate.
“We now have concrete evidence that RLS is an authentic disorder with recognizable features and underlying biological basis,” says David Rye, MD, PhD, professor of neurology at Emory University School of Medicine, director of the Emory Healthcare Program in Sleep, and one of the study’s lead authors. “This is the most definitive link between genetics and RLS that has been reported to date. We have known for quite some time that the majority of RLS patients have a close family member with the disorder, and now we have found a gene which is clearly linked to RLS,” says Dr. Rye.
The researchers report a population-attributable risk for RLS of at least 50 percent, meaning that were the gene variant not present, more than half of all RLS cases would disappear.
The variant is very common–nearly 65 percent of the population carries at least one copy of the variant. Two copies of the variant more than doubles one’s risk of experiencing RLS.
According to Dr. Rye, having two copies does not ensure that one will develop symptoms of RLS. “There remain yet-to-be-identified medical, environmental or genetic factors that appear necessary to translate genetic susceptibility into RLS symptoms,” he says.
RLS researchers have known for some time that anemia and low iron levels contribute to more severe RLS symptoms. The current study revealed the gene variant to be more common in Icelandic subjects deficient in iron.
The medical breakthrough is the result of a four-year study led jointly by Dr. Rye and deCODE Genetics scientist Dr. Hreinn Stefansson. With the goal of identifying genes causing RLS, the research team conducted genome-wide scans of nearly 1,000 Icelanders and 188 Americans. A new chip technology was applied along with genome wide association methods.
This approach allowed Drs. Rye and Stefansson to probe more than 300,000 small regions (single nucleotides) distributed across the entire genome for differences more common to RLS sufferers as compared to population-based controls.
According to Dr. Rye, very little is known about the function of the gene variant discovered.
“Additional work will be required to translate this knowledge into a plausible mechanism and, in turn, more rational and better treatments,” notes Dr. Rye. “Future advances will depend upon additional monies which to this point have come solely from private foundations and industry.”
Dr. Rye says RLS is exceedingly common but not taught as a part of standard medical education, in part leading many medical professionals, educators and academicians to challenge its commonality and authenticity.
Source: Emory University
Nintendo Wii & Table Tennis: A Perfect Match
July 19, 2007
Wii and table tennis are such a perfect match, it’s shocking nobody has come up with it until now. Of course, it helps that Rockstar Games already had a ping pong game that was a critical darling on Xbox 360. Nintendo Wii port, here we come!
Rockstar Games is proud to announce that Rockstar Games presents Table Tennis will be making its way to the Wii home video game system from Nintendo this Fall.
Developed by Rockstar Leeds in collaboration with Rockstar San Diego, Rockstar Games presents Table Tennis is the perfect Wii gaming experience. Feel the unmatched speed and intensity of the real-life sport with an authentic physics engine and intuitive gameplay that mimics the exhilarating experience found in international competition.
Rockstar Games presents Table Tennis made its debut in May 2006 on Xbox 360 video game and entertainment system from Microsoft and was met with huge critical acclaim, winning Gamespot’s “Best Sports Title” at E3 2006.
“Ever since we released Table Tennis, fans have been asking us to create a Wii version,” said Sam Houser, Founder and Executive Producer of Rockstar Games. “By bringing Table Tennis to the Wii and utilizing the motion-sensitive Wii Remote, a new audience can now experience a game that is beautifully designed and impossible to put down.”
Addictive, fast-paced and above all fun, Rockstar Games Presents Table Tennis is guaranteed to be the must have title for all Wii owners.
Source: Rockstar Games
PS3 Boss Talks Nintendo Wii and Xbox 360, Culinary-Style
July 19, 2007
Sony Computer Entertainment America president Jack Tretton recently discussed his company’s own PS3 and PS2, as well as the competition such as Wii as Xbox 360.
But instead of discussing consoles like Nintendo Wii and the 360 as electronic items, he was asked to talk about them as food items.
“I think the PS3 is the Surf ‘n Turf,” he told Gamepro. “You want the lobster and steak and you’re going to give yourself the treat of getting the best thing on the menu. The PS2 is your favorite burger restaurant — you go there for comfort food and it’s just always good and is a good value. [As for the other two consoles], one [Wii] is a lollipop, and I’m too old for lollipops. The other one [Xbox 360] I get sick from once in a while because the cook isn’t always reliable.
Oddly enough, this sort of talk isn’t unprecedented. A few months back, Hideo Kojima, the creator of Metal Gear Solid, compared all three next generation consoles to a movie theater, a DVD, and a television. The metaphor is alive and well in the gaming world.